|
KMID : 1147720170100060402
|
|
Journal of Acupuncture and Meridian Studies
2017 Volume.10 No. 6 p.402 ~ p.408
|
|
|
Antidepressant Effects of Pharmacopuncture on Behavior and Brain-Derived Neurotrophic Factor (BDNF) Expression in Chronic Stress Model of Mice
|
|
Kim Yun-Na
Lee Hwa-Young
Cho Seung-Hun
|
|
|
Abstract
|
|
|
Objectives: The present study aimed to investigate the antidepressant effect of the traditional Korean medical pharmacopuncture, Liver Qi Depression (HJ11), in a mouse model of depression induced by exposure to chronic immobilization stress (CIS).
Methods: Mice were subjected to 2 hours of immobilization stress daily for 14 days. They were also injected with distilled water (DW) (CIS + DW) or HJ11 at the acupoints HT7, SP6, and GV20 (CIS + HJ11) an hour before stress. The positive control group (CIS + paroxetine) was intraperitoneally injected with paroxetine (10 mg/kg, 14 days). The tail suspension test and the forced swimming test were performed to assess depression-like behaviors. Western blotting was also conducted to seek the change in brain.
Results: CIS + DW mice showed significantly longer immobile times in the tail suspension test and forced swimming test than sham mice that did not go through daily restraint. Immobility of CIS + HJ11 and that of CIS + paroxetine mice was significantly decreased compared with immobility of CIS + DW mice. Immunoblotting showed that HJ11 increased the expression of brain-derived neurotrophic factor both in the hippocampus and the amygdala.
Conclusion: HJ11 improves depressive-like behaviors in the stress-induced mouse model of depression, and the results indicate that the neuroprotective effect of HJ11, identified by brain-derived neurotrophic factor expression, may play a critical role in its antidepressant effect.
|
|
|
KEYWORD
|
|
|
amygdala, brain-derived neurotrophic factor, chronic immobilization stress, depression, hippocampus, pharmacopuncture
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
|